A drug called donanemab has been hailed as a “breakthrough” and “turning-point”. That is overblown. But it does mark steady—and welcome—progress
. Then, in 2021, a drug called aducanumab received regulatory approval in America. A second, lecanemab, got the nod in January this year. Now a paper published on July 17th in theIn a trial involving 1,736 people showing early symptoms of Alzheimer’s, donanemab, developed by Eli Lilly, an American firm, was shown to have “significantly slowed” the progression of the disease—by 35% after 76 weeks by one measure.
Like its two predecessors, donanemab is an antibody whose target is a protein, beta-amyloid, that forms clumps, or plaques, in the brains of people with Alzheimer’s. Along with the tangles of another protein, known as tau, these are the defining pathological characteristics of the disease. Aducanumab was developed by Biogen, another American firm, and is still undergoing clinical trials. Its huge cost was not covered by insurers, and it has been rejected by many countries’ regulators.
Belgique Dernières Nouvelles, Belgique Actualités
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