Alzheimer's disease causes death of neurons, and researchers hypothesize this may contribute to abnormal electrical activity in the brain that leads to epileptic seizures.
There appears to be a mechanism at work that puts people living with dementia at higher risk and recurrence of all types of seizures. While we continue our push to find treatments and preventions for Alzheimer's and other dementias, doctors should be aware of how common seizures are in this population to better monitor and treat these individuals.
People with dementia may experience many types of seizures Ruby Castilla-Puentes, MD, DrPH, MBA, director, clinical research, neuroscience, Janssen Pharmaceuticals and colleagues Miguel Habeych, MD, MPH at the University of Cincinnati analyzed a large U.S. national managed care database including more than 2.8 million individuals with and without dementia, age 60 and older. In the database, 79,561 persons had a dementia diagnosis. Of that group, 56% were women.
Related Stories"There may be many reasons for these higher rates, including the medications used to treat dementia, other medical conditions associated with both seizures and dementia, or a combination of factors," said Castilla-Puentes. "More research is needed to answer that question." High recurrence rates and potential negative consequences of epilepsy in dementia In another study reported at AAIC 2019, analysis of data from the National Alzheimer's Coordinating Center, comprising 20,745 individuals at 34 centers between 2005 and 2016, found that prevalence of active seizures was higher in persons with Alzheimer's than in persons without the disease . And persons with Alzheimer's disease were also twice as likely to have had a previous seizure .
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