ADHD diagnosis in childhood vs adulthood: is there a difference in genetic architecture? medrxivpreprint CUBoulder ADHD genetics health childhealth
By Pooja Toshniwal PahariaAug 9 2023Reviewed by Sophia Coveney In a recent study posted to the medRxiv* preprint server, researchers investigated whether individuals diagnosed with attention-deficit hyperactivity disorder during childhood differed from those who were diagnosed during adulthood in terms of unique and shared genetic and functional architectures.
About the study In the present study, researchers investigated the disparities in genomic associations between ADHD identified in adulthood and childhood in terms of psychiatric, behavioral, health, and cognitive outcomes. The ADHD genome-wide association studies for ADHD diagnoses were collected from previously published original research that comprised 38,303, 14,878, and 6,961 Danish controls, pediatric ADHD patients, and adult ADHD patients, respectively.
The study discovered a combination of convergent and divergent genetic markers in adults and children with ADHD. The key distinctions were seen in cognitive and internalizing results. The data indicated that ADHD identified in adulthood had a genetic overlap, notably with the non-cognitive elements that contribute to academic achievement.
Follow-up models exploring the relationship between chronic ADHD and internalizing provided evidence supporting findings against the misdiagnosis hypothesis.
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