A study published in BMCMedicine finds that corticosteroid use at any time during pregnancy in women with Irritable Bowel Syndrome is associated with a 2.5-fold increased risk of preterm birth. Further studies are warranted in this area.
presents the basic study characteristics of the two exposed cohorts and the unexposed cohort, including characteristics of the mother and the childbirth. During the study period, a total of 707 children were born after early pregnancy exposure to corticosteroids, 1336 children were born after exposure at any time during pregnancy, and 9371 children were born to women with IBD who did not receive corticosteroids during pregnancy .
Table 1 Descriptive characteristics of women with inflammatory bowel disease , and their neonates exposed to corticosteroids during pregnancy, and unexposed from 1995 to 2015Across the three cohorts, women had equivalent use of biologic therapy within 30 days prior to conception and during pregnancy. Slightly fewer women used azathioprine in the unexposed cohort; 5.9% vs. 12.9% and 10.8% in the two exposed cohorts. The same pattern was present regarding 5-ASA treatment during pregnancy with 28.
Table 2 The hazard ratio of congenital malformations in live born children exposed in utero to corticosteroids , relative to children not exposed in utero to corticosteroids. Multivariable Cox proportional hazard regression model with crude and adjusted estimates with 95% confidence intervals presents the birth outcomes of preterm birth, small for gestational age and low 5-min Apgar score.
Table 3 Odds of adverse birth outcomes in live-born children exposed in utero to corticosteroids , relative to children not exposed in utero to corticosteroids, multivariable logistic regression models with crude and adjusted estimates with 95% confidence intervals The crude and adjusted HRs for the site-specific infection categories in the offspring are presented in Table. In the group of first infection, covering all measured infections, the adjusted HR was 1.14 .
Although most women with IBD may conceive while their IBD is in remission, disease activity and flares can complicate up to 20% of all pregnancies in women with Crohn’s disease and 35% in women with ulcerative colitis [
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Differences in gut microbiota and its metabolic function among different fasting plasma glucose groups in Mongolian population of China - BMC MicrobiologyBackground Many studies reported the association between gut microbiota and type 2 diabetes mellitus (T2D), but it is still unclear which bacterial genus plays a key role and how the metabolic function of gut microbiota changes in the occurrence and development of T2D. Besides, there is a high diabetic prevalence in Mongolian population, which may be partly affected by their high calorie diet. This study identified the main bacterial genus influencing T2D in Mongolian population, and analyzed the changes of metabolic function of gut microbiome. The association between dietary factors and the relative abundance of main bacterial genus and its metabolic function was also studied. Methods Dietary surveys and gut microbiota test were performed on 24 Mongolian volunteers that were divided into T2D (6 cases), PRET2D (6 cases) and Control group (12 cases) according to fasting plasma glucose (FPG) values. The relative abundance and metabolic function of gut microbiome from their fecal samples were measured by metagenomic analysis. Statistic method was used to evaluate the association between dietary factors and the relative abundance of the main bacterial genus or its metabolic function. Results This study found that the Clostridium genus may be one of the key bacterial genera affecting the process of T2D. First, the relative abundance of Clostridium genus was significantly different among the three groups. Second, there was a higher relative abundance of metabolic enzymes of gut bacteria in PRET2D and T2D group than that in Control group. Third, a strong correlation between Clostridium genus and many metabolic enzymes was uncovered, many of which may be produced by the Clostridium. Last, carotene intake daily was negatively correlated with the Clostridium but positively correlated with tagaturonate reductase catalyzing interconversions of pentose and glucuronate. Conclusions The gut Clostridium genus may play an important role in the development of T2D and it could be a po
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Scholes left riled by 'upbeat' Eriksen interview following Man United horror showPaul Scholes has criticised Christian Eriksen for his ‘upbeat’ post-match interview for Manchester United. The Danish midfielder was part of Erik ten Hag’s side that fell to a 3-0…
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Shocking moment teen sets himself on fire outside US embassy in DenmarkA DANISH teenager set himself on fire in front of the US embassy in Copenhagen today. The fire was put out and the 18-year-old has been rushed to hospital conscious and not in a life-threatening st…
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Normal high-sensitivity cardiac troponin for ruling-out inpatient mortality in acute COVID-19Introduction Assessment of inpatient mortality risk in COVID-19 patients is important for guiding clinical decision-making. High sensitivity cardiac troponin T (hs-cTnT) is a biomarker of cardiac injury associated with a worse prognosis in COVID-19. We explored how hs-cTnT could potentially be used in clinical practice for ruling in and ruling out mortality in COVID-19. Method We tested the diagnostic value of hs-cTnT in laboratory-confirmed COVID-19 patients (≥18 years old) admitted to the Royal Berkshire Hospital (UK) between 1st March and 10th May 2020. A normal hs-cTnT was defined as a value within the 99th percentile of healthy individuals (≤14 ng/L), and an elevated hs-cTnT was defined as |14 ng/L. Adverse clinical outcome was defined as inpatient mortality related to COVID-19. Results A total of 191 COVID-19 patients (62% male; age 66±16 years) had hs-cTnT measured on admission. Of these patients, 124 (65%) had elevated hs-cTnT and 67 (35%) had normal hs-cTnT. On a group level, patients with elevated hs-cTnT had worse inpatient survival (p=0.0014; Kaplan-Meier analysis) and higher risk of inpatient mortality (HR 5.84 [95% CI 1.29–26.4]; p=0.02; Cox multivariate regression) compared to patients with normal hs-cTnT. On a per-patient level, a normal hs-cTnT had a negative predictive value of 94% (95% CI: 85–98%) for ruling out mortality, whilst an elevated hs-cTnT had a low positive predictive value of 38% (95% CI: 39–47%) for ruling in mortality. Conclusions In this study cohort of COVID-19 patients, the potential clinical utility of hs-cTnT appears to rest in ruling out inpatient mortality. This finding, if prospectively validated in a larger study, may allow hs-cTnT to become an important biomarker to facilitate admission-avoidance and early safe discharge.
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Stop the 'prophetic birth of a new miracle child' in this deeply weird MetroidvaniaBlasphemous 2 will be out later this year.
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Emmerdale fans spot problem with Chloe's baby storyline and make demandChloe Harris has given birth during the latest episode of Emmerdale
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