New study reveals dementia risks unique to people with African ancestry MolPsychiatry
Conceptualization: MWL, RS, LAF, VM, MSP, RLH. Formal Analysis: RZ, RS, NS Data Curation: RS, RZ. Data interpretation: RS, RZ, LAF, MWL. Methodology: All authors. Funding Acquisition: MWL, Visualization: MWL, Writing – Original draft: RS, MWL, LAF Writing- editing and approval of the manuscript: All authors. Resources: JMG.
Jennifer R. Fonda, Kelly M. Harrington, Zoe Neale, David Marra, Mark W. Miller, Erika Wolf & Mark W. Logue Translational Research Center for TBI and Stress Disorders and Geriatric Research, Educational and Clinical Center , VA Boston Healthcare System, Boston, MA, USAJennifer R. FondaWilliam S. Kremen, Matthew S. Panizzon, Victoria C. Merritt & Richard L. HaugerWilliam S. Kremen, Matthew S. Panizzon & Richard L.
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Adolescent Δ-9-tetrahydrocannabinol exposure induces differential acute and long-term neuronal and molecular disturbances in dorsal vs. ventral hippocampal subregions - NeuropsychopharmacologyNeuropsychopharmacology - Adolescent Δ-9-tetrahydrocannabinol exposure induces differential acute and long-term neuronal and molecular disturbances in dorsal vs. ventral hippocampal subregions
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Peripheral Auditory Nerve Impairment in a Mouse Model of Syndromic AutismDysfunction of the peripheral auditory nerve (AN) contributes to dynamic changes throughout the central auditory system, resulting in abnormal auditory processing, including hypersensitivity. Altered sound sensitivity is frequently observed in autism spectrum disorder (ASD), suggesting that AN deficits and changes in auditory information processing may contribute to ASD-associated symptoms, including social communication deficits and hyperacusis. The MEF2C transcription factor is associated with risk for several neurodevelopmental disorders, and mutations or deletions of MEF2C produce a haploinsufficiency syndrome characterized by ASD, language, and cognitive deficits. A mouse model of this syndromic ASD ( Mef2c -Het) recapitulates many of the MEF2C haploinsufficiency syndrome-linked behaviors, including communication deficits. We show here that Mef2c -Het mice of both sexes exhibit functional impairment of the peripheral AN and a modest reduction in hearing sensitivity. We find that MEF2C is expressed during development in multiple AN and cochlear cell types; and in Mef2c -Het mice, we observe multiple cellular and molecular alterations associated with the AN, including abnormal myelination, neuronal degeneration, neuronal mitochondria dysfunction, and increased macrophage activation and cochlear inflammation. These results reveal the importance of MEF2C function in inner ear development and function and the engagement of immune cells and other non-neuronal cells, which suggests that microglia/macrophages and other non-neuronal cells might contribute, directly or indirectly, to AN dysfunction and ASD-related phenotypes. Finally, our study establishes a comprehensive approach for characterizing AN function at the physiological, cellular, and molecular levels in mice, which can be applied to animal models with a wide range of human auditory processing impairments. SIGNIFICANCE STATEMENT This is the first report of peripheral auditory nerve (AN) impairment in a mouse
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