New AIalgorithm could boost COVID-19 mRNA vaccine antibody response by 128 times nature
Messenger RNA vaccines are being used to contain COVID-19 , but still suffer from the critical limitation of mRNA instability and degradation, which is a major obstacle in the storage, distribution, and efficacy of the vaccine products . Previous work showed that increasing secondary structure lengthens mRNA half-life, which, together with optimal codons, improves protein expression . Therefore, a principled mRNA design algorithm must optimize both structural stability and codon usage.
On both COVID-19 and varicella-zoster virus mRNA vaccines, LinearDesign substantially improves mRNA half-life and protein expression, and dramatically increases antibody titer by up to 128×, compared to the codon-optimization benchmark. This surprising result reveals the great potential of principled mRNA design, and enables the exploration of previously unreachable but highly stable and efficient designs.
Belgique Dernières Nouvelles, Belgique Actualités
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