All SARS-CoV-2 variants blocked by a simple peptide with nanomolar neutralizing efficacy Efficacy SARSCoV2 Coronavirus Disease COVID Stanford harvardmed helsinkiuni UCBerkeley UVA PNASNews
Study: Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike protein. Image Credit: Kateryna Kon / Shutterstock
Previously, researchers have used several structural engineering approaches to make more effective HR2-based inhibitors based on 36 amino acid segments of SARS-CoV-2 S residues 1168–1203. The researchers developed two assays to detect complex formation between HR2 variants and HR1 and a cell-cell fusion assay to test the effects of the N-terminal extension of HR2 on inhibiting the membrane-fusion function of SARS-CoV-2 S.
Schematic of SARS-CoV-2 infection and inhibition by HR2 peptides. SARS-CoV-2 binds the host cell receptor ACE2 through an interaction with the S1 domain of the S protein. After cleavage by host cell proteases, the S1 domain is released and the S2 domain of the S protein extends into the host cell membrane.
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