Antibiotic-resistant bacteria get extra nutrients and thrive when the drugs kill 'good' bacteria in the gut.
This is according to new research led by Imperial College London scientists, which could lead to better patient risk assessment and 'microbiome therapeutics' treatments to help combat antibiotic-resistant bacteria.
Now, a new study shows how these resistant bacteria thrive after antibiotic use, allowing them to multiply in the gut, forming a 'reservoir' of disease-causing bacteria. The results are published in Nature Communications. The team also showed that killing beneficial bacteria reduced the level of metabolites - waste products that inhibit pathogenic bacteria from growing further. This helped the pathogenic bacteria to thrive.
Microbiome therapeutics The team are now working on ways to interfere with this process. First, they want to identify which beneficial bacteria can 'out-compete' pathogenic bacteria in the absence of antibiotics: which good bacteria are able to make better use of the same nutrients and produce metabolites that restrict pathogenic bacterial growth.
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