Are mushrooms an effective early dietary intervention for Alzheimer’s Disease? Foods_MDPI mushrooms diet food health disease AlzheimersDisease AD
Their review highlights how bioactive compounds in mushrooms, especially neuroprotective small molecules, might help delay the onset and progression of the condition and present mushrooms as a functional food and early dietary intervention for individuals living with the disease.
Pathologically, AD is predominantly identified and characterized by excess deposition of extracellular beta-amyloid plaques and tau tangles . While research into the pathology of AD is ongoing, the mechanisms behind AD progression remain elusive, with no cure currently available for the condition. AD is a multifactorial condition, with studies identifying genetic, environmental, dietary, age, and sociodemographic contributors to AD prevalence and progression.
“Whole plant foods, such as mushrooms, berries, garlic, and turmeric, were found to effectively prevent and improve cognitive deficit via regulating the main pathway of neuroinflammation, lipoxin A4 -nuclear factor-kappa B , and mitogen-activated protein kinases .
The magic of mushrooms Mushrooms are the fleshy, spore-bearing fruiting body of macrofungi, typically produced above ground on soil or their food source. Studies on Hericium erinaceus have shown that its extracts and biomolecules effectively reversed cognitive and behavioral deficits in both preclinical animal trials and, remarkably, in clinical human trials.
Similar in vitro studies on murine models using polysaccharide extracts from Grifola frondosa , Pleurotus eryngii , and H. erinaceus all described neuroprotective and antioxidant properties in aging rats. The rats showed significantly improved cognition implying a reversal of neurodegeneration.
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