Are teicoplanin-non-susceptible Staphylococcus epidermidis strains increasing?

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Are teicoplanin-non-susceptible Staphylococcus epidermidis strains increasing?
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Are teicoplanin-non-susceptible Staphylococcus epidermidis strains increasing? SciReports staphylococcus strains strains increasing bacteria microbiology

By Susha Cheriyedath, M.Sc.Aug 8 2023Reviewed by Sophia Coveney In a recent study published in the journal Scientific Reports, researchers elucidated the incidence patterns of teicoplanin-non-susceptible Staphylococcus epidermidis over six years . Background S. epidermidis, a Coagulase-Negative Staphylococci family member, is widely recognized as the CoNS species most commonly linked to clinically manifested infections.

However, in recent years, the number of S. epidermidis strains having minimal inhibitory concentrations =8 or ≥ 16 mg/L has increased. Researchers exempted patients with multiple infections, non-hospitalized patients, strains cultured within two days of patient enrollment, strains cultured frequently within three months, no susceptibility results, patients less than 18 years, and patients where culture test results changed.

The age and MIC data were analyzed using the interquartile range and the median tests. Fisher's exact test and the chi-square test were used for comparison between groups; P values under 0.05 were regarded as statistically significant. Data were expressed using frequencies or percentages, and statistical analysis was conducted using SPSS version 26.0.

The study compared the clinical traits of strains in the Teico-NS and Teico-S groups. The Teico-NS group had significantly older patients, higher diabetes mellitus, and a higher coronavirus disease 2019 infection prevalence.

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