A new method to assess the status of immune responses to specific antigens in detail by analysis using the B cell receptor (BCR) repertoire has been developed by a research group, consisting of Assistant Professor Yohei Funakoshi, Associate Professor Kimikazu Yakushijin, Professor Hironobu Minami (Kobe University Graduate School of Medicine), Associate Professor Goh Ohji (Kobe University Hospital), and Researcher Takaji Matsutani (Repertoire Genesis Inc.).
Previously, B-cell receptor repertoire analysis has provided gene sequence data of antibodies , but it was difficult to use this data to evaluate the immunological reactions to specific antigens.
Detailed information can be derived, such as antibody epitopes expressed in immunological reactions or neutralization activity, if there is additional information in respect of the antibodies used. By utilizing this method to investigate immune responses following the administration of mRNA vaccines, it will be possible to evaluate the functionality of mRNA formulations.
However, say the researchers, antibody prophylaxis is not a complete substitute for vaccination. It is recommended that regular vaccines be administered even in cases where prophylaxis has already been administered. In such cases, the immunological reaction is typically assessed after vaccine inoculation by measuring antibodies using the ELISA method.
A: Tixagevimab/Cilgavimab was administered to cases after umbilical cord blood transplant and were inoculated with the mRNA vaccine thereafter . The anti-SARS-CoV-2 antibody titer transitioned to an extremely high titer value after prophylactic antibody administration, but even then the researchers were able to assess the reactions after vaccine inoculation by assessing SARS-CoV-2 specific sequences .
For that reason, against the background of the recent COVID-19 pandemic, the researchers focused on the fact that a vast amount of information on SARS-CoV-2 antibody sequences has been accumulated and compiled into databases. Using this database, they focused on sequences that were reported to bind to a specific antigen , or sequences similar to it, and conducted analysis, enabling them to evaluate post-vaccination responses.
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New method to assess the status of immune responses to specific antigens in detailA new method to assess the status of immune responses to specific antigens in detail by analysis using the B cell receptor (BCR) repertoire has been developed by a research group, consisting of Assistant Professor Yohei Funakoshi, Associate Professor Kimikazu Yakushijin, Professor Hironobu Minami (Kobe University Graduate School of Medicine), Associate Professor Goh Ohji (Kobe University Hospital), and Researcher Takaji Matsutani (Repertoire Genesis Inc.).
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