Oral bacteria may increase heartdisease risk elife elife
1. Multiple risk factors were investigated in univariable analysis before their combination into multivariable models. The authors should add to the discussion multiple testing implications
We performed a t-test to compare levels of biomarkers of inflammation between seronegative and seropositive individuals. The results showed no statistical difference in hs-CRP or TNF-a levels according toPrevious studies have shown that elevated levels of inflammatory markers in the blood, such as hs-CRP, are indeed associated with an increased risk of developing CHD . In our study, we also observed significant association between CRP and the occurrence of CHD, independent ofserological status.
8. Supplementary figure 1: scatter plot involving income looks odd. Best fit line does not make sense with income categorised We thank you for this suggestion. We now use Cramer's V coefficients, which are more appropriate than the correlation coefficient in this context, and adapted the Methods section accordingly.The manuscript is very well organized and has several strengths. The methodology is very solid.
2. Although I do think the results are sound, the study is overall descriptive and do not provide any support toward a mechanism until we get into the discussion.
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The association between cannabis use and sleep complaints in University studentsThe association between cannabis use and sleep complaints in University students univbordeaux CHUBordeaux univ_paris_cite cannabis sleep student health insomnia
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How are changes in coffee and caffeine intake associated with changes in fat tissue?How are changes in coffee and caffeine intake associated with changes in fat tissue? unav HarvardChanSPH coffee caffeine fat faittissue health
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Shorter sleep among adolescents is associated with lower fruit and vegetable consumption the following day - International Journal of Behavioral Nutrition and Physical ActivityBackground Insufficient sleep has been associated with weight gain and metabolic dysregulation, with one suggested mechanism being through reduction in diet quality. Experimental evidence supports a causal effect of sleep timings on diet but this may not be applicable to a free-living adolescent population. In this analysis we use daily measures of sleep timings and diet quality, to examine the effect of sleep duration and timing on diet quality the following day among free-living adolescents. Methods The ROOTS study is a prospective cohort recruited from secondary schools in Cambridgeshire and Suffolk (UK). Participants (n = 815) at mean age 15.0y (SD 0.3y) completed a diet diary and wore a combined heart rate and accelerometer device over 4 consecutive days. Sleep duration and timing (midpoint) were derived from acceleration and heart rate traces, while daily energy density and fruit and vegetable intake were calculated from dietary data. Analyses were performed at day-level (1815 person-days). Multilevel random effects models were used to test associations between sleep each night and subsequent day diet, with daily sleep and diet measures nested within individuals and schools, and adjusted for day-level and individual-level confounding variables. Results Adolescents slept a mean of 7.88 hrs (SD 1.10) per night, reporting a mean energy density of 2.12 kcal/g (SD 0.48) and median energy-adjusted daily fruit and vegetable intake of 137.3 g (IQR 130.4). One hour shorter sleep duration was associated with lower intake of fruit and vegetables (-6.42 g, 95%CI -1.84, -10.99) the following day. An association with higher dietary energy density (0.016 kcal/g, 95%CI 0.034, -0.002) the following day was observed but did not reach statistical significance. Sleep timing was not associated with either fruit and vegetable intake (-2.52 g/d, 95%CI -7.66, 2.62) or dietary energy density (-0.001 kcal/g, 95%CI -0.022, 0.020). Conclusions Our observational findings from a free-livin
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Fatal health problem affecting Manchester 'more than anywhere else in England'The fatal health problem that affects Greater Manchester almost 'more than anywhere else in the country'
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Parents of 'miracle baby' born with deadly heart defect facing homelessnessHannah Marsden and her partner Michael are being evicted from their home after falling behind on rent
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