Boosting gut health with short-chain fatty acids Cardiometabolic FattyAcids ShortChainFattyAcids SCFAs GutHealth Microbiota Prebiotics IBD InflammatoryBowelDiseases ColorectalCancer Nutrients_MDPI
By Pooja Toshniwal PahariaMay 9 2023Reviewed by Benedette Cuffari, M.Sc. In a recent review published in the journal Nutrients, researchers review existing data on short-chain fatty acids , such as butyrate, acetate, and propionate, as critical constituents of the human intestinal microbiome.
SCFAs in human health SCFA transporters present on the epithelial surface of the colon including monocarboxylate transporter-1 and MCT-4, sodium-coupled MCT-1 , and breast cancer resistance protein mediate the effects of SCFA on the intestines. SCFAs have also been shown to inhibit histone deacetylase activity and, as a result, may influence the pathophysiology of neuropsychiatric disorders such as Alzheimer’s disease, schizophrenia, and depression.
Furthermore, SCFAs lower myeloperoxidase levels and decrease inflammatory cell chemotaxis by decreasing monocyte chemoattractant protein-1 and vascular cell adhesion molecule-1 levels. SCFAs also increase regulatory T cell counts and reduce intestinal inflammation by lowering nuclear factor-kappa B activity and associated cytokine release.
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