The study uses Mendelian randomization to examine the relationship between 14 micronutrients and 22 cancer outcomes, finding significant associations between higher magnesium and vitamin B12 levels and increased risks of breast and colorectal cancers, respectively.
By Tarun Sai LomteAug 27 2023Reviewed by Benedette Cuffari, M.Sc. In a recent study published in the journal BMC Medicine, researchers evaluate the associations between micronutrients and cancer outcomes.
Mendelian randomization analyses address these challenges by incorporating genetic variants as instrumental variables to evaluate the causal relationship between disease and risk factors. The health benefits of micronutrients described in observational studies over the past decade are not causal associations in MR analyses.
Likewise, data were used from GWASs from the FinnGen study, the United Kingdom Biobank study, and other cancer consortia for cancer outcomes. GWASs were available for 22 cancer outcomes from the FinnGen and U.K. Biobank cohorts. Summary statistics from these cohorts were meta-analyzed for each cancer outcome.
The inverse variance-weighted method was used to obtain the summary of the association. Bonferroni correction was applied for multiple testing. The remaining 16 associations showed an increased or decreased risk of cancer outcomes with increased micronutrient levels. Micronutrient levels were not associated when the overall cancer risk was considered. Further, 10 out of 84 associations were significant in the MR analyses of six additional cancer outcomes.
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