Cannabis users with a genetic predisposition to schizophrenia more likely to experience psychotic symptoms Cannabis Genetic Schizophrenia Alcohol Depression Hallucination Paranoia SchizBulletin
Study: Associations Between Cannabis Use, Polygenic Liability for Schizophrenia, and Cannabis-related Experiences in a Sample of Cannabis Users. Image Credit: StunningArt / Shutterstock
In the current study, scientists have investigated whether genetic risk for schizophrenia is associated with cannabis intake-related psychotic-like experiences, including hallucination, paranoia, depression, cognitive difficulties, and impaired social interaction. Statistical analyses were conducted to determine whether polygenic risk for schizophrenia is associated with cannabis-related experiences in individuals who reported using cannabis at least 11 times.
A significant association between lifetime diagnosis of cannabis use disorders and earlier age at first-time cannabis use was observed with reporting of cannabis-related experiences. Except for hallucination and paranoia, all other cannabis-related experiences showed significant associations with the duration of daily cannabis use. Moreover, a strong association was observed between the severity of cannabis use disorder and endorsing a higher number of cannabis-related experiences.
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