Characterization of anti-orthopoxvirus antibody response in general population and gay men medrxivpreprint OrthopoxVirus Mpox MpoxVIrus AntibodyResponse
By Dr. Sanchari Sinha Dutta, Ph.D.Dec 22 2022Reviewed by Aimee Molineux A team of China-based scientists has recently estimated and compared the levels of anti-mpox and anti-vaccinia antibodies in gay men and the general population. The study is currently available on the medRxiv* preprint server.
Smallpox is a life-threatening infection caused by the variola virus, which also belongs to the same Orthopoxvirus genus. Vaccines developed against smallpox are, thus, expected to provide cross-protection against mpox infection. In the current study, scientists have estimated and compared the blood levels of anti-mpox and anti-vaccinia antibodies in MSM and the general population residing in China. They have also compared the antibody responses in people born before and after 1981. In China, the smallpox vaccination ended in 1981.
Peripheral blood samples were collected from the participants to measure the levels of binding and neutralizing antibodies targeting specific proteins of the mpox virus and vaccinia virus. Neutralizing antibody response The scientists measured the levels of anti-vaccinia neutralizing antibodies with the speculation that the antibodies may provide a cross-reactive neutralizing response against the mpox virus.
The analysis identified a positive correlation between anti-mpox and anti-vaccinia binding antibody responses in general adults born before 1981. However, no such correlation was detected in MSM and general adults born after 1981.
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