A study published in BMCPediatr provides preliminary information on virological aspects of the relationship between the microbiome and autism spectrum disorder. The authors suggest larger studies to find if more microbiomes may be associated with autism.
], and it has been demonstrated that alterations in the intestinal virome, especially the DNA virome, may be important factors in diseases such as inflammatory bowel disease, colorectal cancer, diabetes, and Parkinson's disease. Therefore, the study of the gut DNA virome is an important and valuable approach to study the pathogenesis of diseases.
Here we conducted a case–control study to explore the differences in the gut DNA virome compared to non-autistic children, which might play a role in ASD. First, we recruited children with ASD from the same family to participate together with their healthy siblings, taking into account age, mode of birth, history of antibiotic use, and vaccination history to reduce the influence of confounding factors and to improve the accuracy of the test results.
Belgique Dernières Nouvelles, Belgique Actualités
Similar News:Vous pouvez également lire des articles d'actualité similaires à celui-ci que nous avons collectés auprès d'autres sources d'information.
BMC Roadmachine TWOReview: BMC Roadmachine TWO - Really fun, if quite stiff for an endurance bike. cycling Ride_BMC
Lire la suite »
Altered expression of anti-apoptotic protein Api5 affects breast tumorigenesis - BMC CancerBackground Apoptosis or programmed cell death plays a vital role in maintaining homeostasis and, therefore, is a tightly regulated process. Deregulation of apoptosis signalling can favour carcinogenesis. Apoptosis inhibitor 5 (Api5), an inhibitor of apoptosis, is upregulated in cancers. Interestingly, Api5 is shown to regulate both apoptosis and cell proliferation. To address the precise functional significance of Api5 in carcinogenesis here we investigate the role of Api5 in breast carcinogenesis. Methods Initially, we carried out in silico analyses using TCGA and GENT2 datasets to understand expression pattern of API5 in breast cancer patients followed by investigating the protein expression in Indian breast cancer patient samples. To investigate the functional importance of Api5 in breast carcinogenesis, we utilised MCF10A 3D breast acinar cultures and spheroid cultures of malignant breast cells with altered Api5 expression. Various phenotypic and molecular changes induced by altered Api5 expression were studied using these 3D culture models. Furthermore, in vivo tumorigenicity studies were used to confirm the importance of Api5 in breast carcinogenesis. Results In-silico analysis revealed elevated levels of Api5 transcript in breast cancer patients which correlated with poor prognosis. Overexpression of Api5 in non-tumorigenic breast acinar cultures resulted in increased proliferation and cells exhibited a partial EMT-like phenotype with higher migratory potential and disruption in cell polarity. Furthermore, during acini development, the influence of Api5 is mediated via the combined action of FGF2 activated PDK1-Akt/cMYC signalling and Ras-ERK pathways. Conversely, Api5 knock-down downregulated FGF2 signalling leading to reduced proliferation and diminished in vivo tumorigenic potential of the breast cancer cells. Conclusion Taken together, our study identifies Api5 as a central player involved in regulating multiple events during breast carcinogenesis includi
Lire la suite »
The effect of intradialytic exercise on dialysis patient survival: a randomized controlled trial - BMC NephrologyBackground Patients with kidney failure have a high mortality rate. This study aimed to evaluate the effect of intradialytic exercise on survival in patients receiving hemodialysis (HD). Methods In this randomized controlled trial conducted in a HD center in Iran, adult patients receiving chronic HD were randomized to intradialytic exercise (60 min) in the second hour of thrice weekly dialysis for 6 months (intervention) or no intradialytic exercise (control). The primary outcome was survival rate at 12 months. Secondary outcomes were serum albumin, hemoglobin, hematocrit, red blood cell count, serum calcium, serum phosphorous, parathyroid hormone, physical function (6-min walk test) and nutritional status (Geriatric Nutritional Risk Index) during the first 6 months. The trial follow-up period was 12 months. Results The study included 74 participants (44 males) with an age average of 64 ± 12 years old and a dialysis history of 27 ± 12 months, randomized to intervention (n = 37) or control (n = 37). Compared with controls, 1-year survival was higher in the intervention group (94% vs 73%, P = 0.01). The hazard ratio in univariate analysis in intervention group was 0.17 (95% CI 0.04–0.8; P = 0.02) compared to that in control group. During the 6-month intervention period, significant between-group changes were observed in all secondary outcomes between the intervention and control groups. Conclusion Intradialytic exercise performed for at least 60 min during thrice weekly dialysis sessions improves survival in adult patients receiving HD. Trial registration ClinicalTrials.gov Identifier: NCT04898608. Retrospectively registered on 24/05/2021. Registered trial name: The Effect of Intradialytic Exercise on Dialysis Patients Survival.
Lire la suite »
Rainbow Ramble brings a blaze of colour to village streets in aid of children's charityWalkers brought an explosion of colour to the village of Croston in the annual Rainbow Ramble for a children’s charity.
Lire la suite »
Asylum seeker's children living in hotel 'won't eat unsuitable food'Hyre and her two children, aged 14 and 16, moved to the UK from Albania last year.
Lire la suite »
Disabled children locked out of £210m in savings as senior Tories demand trust fund rule change90% of 18 year olds who lack the mental capacity to manage their finances are locked out of the money saved for them by their parents under the Child Trust Fund scheme, new figures show ⬇️ Senior Tories are demanding a change to the rules
Lire la suite »