Cholesterol medication fenofibrate fails to cut severe symptoms or death in COVID-19 patients pennmedicine
After showing promise in early laboratory research, the cholesterol-lowering drug fenofibrate had no significant effect on COVID-19 outcomes in a multicenter international randomized clinical trial led by Penn Medicine scientists.
The drug was initially targeted for COVID-19 research as part of an effort to test older, previously approved drugs for potential benefit against the virus. In laboratory studies, it was found that excessive production of certain fat molecules by cells is involved in thecaused by SARS-CoV2. Fenofibrate affected the way cells handle fat in a way that reduced viral replication.
Patients were then ranked based on a novel severity score system that measured disease severity along with factors including death, the use of invasive and non-invasive ventilators, length of hospital stay, as well as time to hospitalization and symptom severity among outpatients.had no significant effect either on severity scores or death from any cause, among other metrics. There was similarly no difference in outcomes up to 30 days after the initial randomization.
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