Technique for tracking resistant cancer cells could lead to new treatments for relapsing breastcancer patients Cambridge_Uni elife
Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, United KingdomGregory J Hannon, Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, United Kingdom
Thomas Ashmore, Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, United Kingdom Hannah Casbolt, Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, United Kingdom Tatjana Kovačević, Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, United Kingdom
Sophia A Wild, Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, United KingdomHamid Raza Ali, Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, United Kingdom Ciara H O'Flanagan, Department of Molecular Oncology, BC Cancer, part of the Provincial Health Services Authority, Vancouver, Canada
Shankar Balasubramanian, Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, United Kingdom Jonas Windhager, Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, United Kingdom Brett Pryor, McGovern Institute, Departments of Biological Engineering and Brainand Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, United States
Yangning Lu, McGovern Institute, Departments of Biological Engineering and Brainand Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, United States Lauren Deighton, Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, United Kingdom Oscar M Rueda, Department of Oncology and Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom
John Marioni, Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, United Kingdom
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Gaseous nitric oxide tumor ablation induces an anti-tumor abscopal effect - Cancer Cell InternationalBackground In-situ tumor ablation provides the immune system with the appropriate antigens to induce anti-tumor immunity. Here, we present an innovative technique for generating anti-tumor immunity by delivering exogenous ultra-high concentration (| 10,000 ppm) gaseous nitric oxide (UHCgNO) intratumorally. Methods The capability of UHCgNO to induce apoptosis was tested in vitro in mouse colon (CT26), breast (4T1) and Lewis lung carcinoma (LLC-1) cancer cell lines. In vivo, UHCgNO was studied by treating CT26 tumor-bearing mice in-situ and assessing the immune response using a Challenge assay. Results Exposing CT26, 4T1 and LLC-1 cell lines to UHCgNO for 10 s–2.5 min induced cellular apoptosis 24 h after exposure. Treating CT26 tumors in-situ with UHCgNO followed by surgical resection 14 days later resulted in a significant secondary anti-tumor effect in vivo. 100% of tumor-bearing mice treated with 50,000 ppm UHCgNO and 64% of mice treated with 20,000 ppm UHCgNO rejected a second tumor inoculation, compared to 0% in the naive control for 70 days. Additionally, more dendrocytes infiltrated the tumor 14 days post UHCgNO treatment versus the nitrogen control. Moreover, T-cell penetration into the primary tumor was observed in a dose-dependent manner. Systemic increases in T- and B-cells were seen in UHCgNO-treated mice compared to nitrogen control. Furthermore, polymorphonuclear-myeloid-derived suppressor cells were downregulated in the spleen in the UHCgNO-treated groups. Conclusions Taken together, our data demonstrate that UHCgNO followed by the surgical removal of the primary tumor 14 days later induces a strong and potent anti-tumor response.
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Sam Heughan appears at Glasgow book signing as he meets starstruck fansSam's new book is a combination of a memoir and travel writing.
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Suella Braverman defends 'compassionate' and 'rational' Rwanda deportation plan after court rules scheme is lawful'This decision thoroughly vindicates the Rwanda partnership' says the Home Sec - adding 'the sooner it is up and running, the sooner we break the business model of the evil gangs'. She then 'invited' the opposition to 'get behind this plan'. 📺 Sky 501
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WIN 12 Days of Christmas: Bravado bra bundleHaving recently celebrated their 30th birthday, Bravado Designs...
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