A study in Parasites and Vectors finds that dengue and Zika viruses simultaneously establish infection in the Ae. aegypti vector, mutually enhancing replication. The intersecting NS5 protein in these coinfections can be a target for vector control.
]. This may occur following an infectious BM from a single human co-viremic for DENV and ZIKV, or when mosquitos acquire sequential BMs from two individuals, each infected with a different virus. DENV and ZIKV share a highly conserved non-structural protein repository consisting of five enzymes/subunits , which associate closely to form a tightly-regulated RC.
In the present study, we observed significant enhancements in virus production and vector susceptibility following DENV2-ZIKV co-infection in, and we demonstrated the cellular and molecular bases of these effects. In co-infected mosquito cells, we found that DENV2 expression was significantly enhanced, whereas ZIKV was coincidentally markedly suppressed and virus production was significantly increased for both.
Our findings describe for the first time the potent mutualistic outcomes of flaviviral co-infection for viral replication, and suggest that vector competence may be enhanced as a result. Vector competence in the arboviral sylvatic cycle is defined by the extent to which the mosquito permits a virus to utilize its circulatory system.
Belgique Dernières Nouvelles, Belgique Actualités
Similar News:Vous pouvez également lire des articles d'actualité similaires à celui-ci que nous avons collectés auprès d'autres sources d'information.
UK's first human cases of bird flu will raise concerns but risk to people remains very smallHow concerned should we be that two human cases of bird flu have been identified in the UK? 🔎 Analysis from janemerrick23
Lire la suite »
The discovery of a novel orthonairovirus from Dermacentor silvarum ticks near the China–North Korea borderThe discovery of a novel orthonairovirus from Dermacentor silvarum ticks near the China–North Korea border CDCgov ticks virus orthonairovirus china korea novelvirus transmission
Lire la suite »
Universal flu jab moves one step closer - paving way for end to yearly vaccinationsA new flu jab is being trialled that could protect against all strains of the virus - eliminating the need for seasonal vaccines and helping protect against potential future pandemics.
Lire la suite »
The worst-case scenario for bird flu would include jabs, severe illness, and human spreadWe ask scientists how they think the avian flu virus is likely to develop following the discovery of two more infected UK people ⬇️ BawdenTom explains
Lire la suite »
Why we should not worry about bird flu cases in humans - yetScientific experts say the discovery of two cases in poultry farm workers in England shows how surveillance of the virus is working, but the H5N1 strain needs to be closely monitored janemerrick23 reports
Lire la suite »