Comparing severe outcome risks of SARS-CoV-2 Omicron BA.2.75, BQ.1, BA.4.6 to BA.5 medrxivpreprint COVID19 coronavirus covid Omicron
By Shanet Susan AlexJul 20 2023Reviewed by Benedette Cuffari, M.Sc. In a recent study posted to the medRxiv* preprint server, researchers determine the clinical severity of the severe acute respiratory syndrome coronavirus 2 Omicron sub-lineages BA.4.6, BQ.1, and BA.2.75 relative to BA.5 in England.
Does Omicron cause more severe infections? Since the emergence of the SARS-CoV-2 Omicron variant in late 2021, numerous Omicron sub-lineages have emerged and spread internationally. The widespread transmission of Omicron sub-lineages has raised concerns about probable immune evasion to therapeutic agents and vaccines. The relative severity of infection with these sub-lineages remains unknown and further research is needed to guide public health interventions.
Patient data were obtained from the Second Generation Surveillance System , which is a national monitoring system that stores test results from England diagnostic labs for notifiable infectious illnesses. Multivariable conditional regression assessments were used to evaluate the likelihood of hospital admission and mortality rates among subjects with Omicron sub-lineage infections as compared to Omicron BA.5 infections.
Related StoriesPatients aged 60 years or older, those who were either partially vaccinated or unvaccinated, and those with underlying medical conditions had higher hospitalization and death rates that were associated with Omicron BA.4.6, BA.5, BQ.1, and BA.2.75 variants. After adjusting for confounding factors, the results suggested that people infected with the Omicron BQ.1 sub-lineage had higher admission or mortality rates; however, there was not enough data to confirm this association. Similarly, there was no evidence that those infected with the Omicron BA.4.6 and BA.2.75 sub-lineages had variations in mortality or hospital admission than those infected with the Omicron BA.5 variant.
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