Research team proves how neurotransmitter may be key in controlling Alzheimer's toxicity NatureChemistry
The progression of neurodegenerative disorders can lead to impaired neurotransmission; however, the role of pathogenic factors associated with these diseases and their impact on the structures and functions of neurotransmitters have not been clearly established.
Here we report the discovery that conformational and functional changes of a native neuropeptide, somatostatin , occur in the presence of copper ions, metal-free amyloid-β and metal-bound Aβ found as pathological factors in the brains of patients with Alzheimer’s disease. These pathological elements induce the self-assembly of SST and, consequently, prevent it from binding to the receptor.
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