Cross-modality supervised image restoration enables nanoscale tracking of synaptic plasticity in living mice - Nature Methods

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Cross-modality supervised image restoration enables nanoscale tracking of synaptic plasticity in living mice - Nature Methods
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Scientists use machinelearning to 'see' how the brain adapts to different environments naturemethods

, could further alleviate the challenge of synapse tracking by aligning all detected synapses automatically.

Overall, the biological and computational tools presented here provide a framework to study synapse plasticity longitudinally at high resolution. Using XTC, future experiments can now readily advance the development of detection and tracking algorithms to interrogate the spatiotemporal relationship between changes in synaptic strength and animal behavior.

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