University of Alberta researchers are repurposing handheld lactic acid testing devices that were originally developed for endurance athletes in North America as a tool to save the lives of critically ill children in sub-Saharan Africa.
, which is why children are most vulnerable. Those who survive may experience cognitive delays, liver and kidney damage.decrease due to strenuous exercise, heart failure or infection. High-performance athletes monitor lactic acid to know when they have reached the threshold between aerobic and anaerobic exercise, a threshold that goes up as they get fitter. You can tell lactic acid is building up in muscles as you exercise when they feel painful and weak, a sign it's time to rest.
Lactic acid buildup has several causes and consequences for children with malaria. The parasites that cause malaria produce lactic acid, so patients with a high parasitic load will have more lactic acid in their blood. The parasites also cause blockages in blood vessels, which can prevent oxygen delivery and tissues that lack oxygen also produce more lactate. The body can't clear lactate efficiently through the kidneys and the liver if they are not functioning properly.
"You can imagine having a three-year-old child come in: they're crying, they're upset. You're trying to determine if they're having respiratory distress and how is this respiratory distress worse than the kid next to them who's also crying and upset," she says."It can be really tricky to figure out which child really needs immediate intervention versus a child that is potentially not as severely ill.
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