New biomarker confirmed for earlydiagnosis of multiple sclerosis
The optic nerve has been recommended as an additional region for demonstrating dissemination in space in diagnostic criteria for multiple sclerosis .To investigate whether adding the optic nerve region as determined by optical coherence tomography as part of the DIS criteria improves the 2017 diagnostic criteria.
Fulfilling DIS+OCT criteria indicated a similar risk of a second clinical attack compared to a 2.5-fold increased risk when fulfilling DIS criteria . When the analysis was conducted according to topography of the first demyelinating event, DIS+OCT criteria performed similarly in both optic neuritis and non–optic neuritis.Addition of the optic nerve, assessed by OCT, as a fifth region in the current DIS criteria improves diagnostic performance by increasing sensitivity without lowering specificity.
Belgique Dernières Nouvelles, Belgique Actualités
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