Anticancerdrugs: A new hope for sepsis treatment FCGulbenkian elife
RNA-seq data for the expression of TNF in the different conditions tested, shown as an example of Epirubicin -regulated NF-κB target gene.
2. A related significant concern is the use of the"kB-33 promoter sequence" in the NMR study . The description of this NF-κB binding sequence was insufficient in the manuscript. In fact, this sequence is not even a"promoter" sequence as stated. This is an artificial sequence derived from a duplication of the 3' half of the immunoglobulin kappa kB enhancer element , which was cited in the Chen et al. 1998 paper which was in turn cited by the authors.
Because of the reduction of circulating TNF levels in the sepsis mouse model after anthracycline treatment, the reviewer suggested the measurement of a physiological outcome, more specifically the kinetics of death. Indeed, the physiological relevance of anthracyclines in sepsis was the central focus of a previous study conducted by our laboratory, published in Immunity in 2013 .
3. The authors uses the term"inflammation" multiple times in the text to describe the induction of inflammatory genes in BMDM, but this term is misleading because inflammation refers to a physiological reaction in vivo. The authors should consider the use of more accurate description.
Belgique Dernières Nouvelles, Belgique Actualités
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