Does fenofibrate improve clinical outcomes in patients with COVID-19? NatMetabolism Penn udes_oficial COVID19 coronavirus covid metabolism
By Bhavana KunkalikarNov 9 2022Reviewed by Danielle Ellis, B.Sc. In a recent study published in Nature Metabolism, researchers assessed the effect of fenofibrate on acute coronavirus disease 2019 .
A prospective, multicenter, randomized, double-blinded study called the FERMIN trial was performed at 25 centers located across six countries, including Colombia, Greece, Lebanon, Mexico, Peru, and the United States. The team assessed the eligibility of participants receiving evaluations in emergency clinics, outpatient clinics, or other emergent/urgent care settings, as well as those hospitalized with COVID-19.
Results The study cohorts included 701 randomized people. The average age of eligible participants was 49 ± 16 years. The cohort included 330 females, 102 patients having diabetes mellitus, 47 having ischemic heart disease, 186 having hypertension while 302 were inpatients. Almost 351 participants were randomly assigned to receive fenofibrate, while 350 others received a placebo.
There were a total of 41 deaths, among which 19 were in the fenofibrate arm and 22 in the placebo arm. There was no discernible difference in all-cause mortality at 30 days between the arms after adjusting for age, gender, outpatient versus inpatient status, baseline FiO2/SpO2, BMI, ethnicity, race, diabetes status, and county. Between the two arms, there were no discernible differences in the Kaplan-Meier failure estimates.
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