Substance use linked to long-lasting brain changes, cognitivedecline tamu NatureComms
The operant chambers contained a house light, a white noise speaker, and two retractable levers on the right wall. Between the two levers, there were adjacent food and sucrose magazines, which shared a common sensor. The training protocols were written in Graphic State, and the chambers were controlled using Graphic State RT.All rats were food-deprived for at least 3 d before training to bring their body weights down to 85% of their free weight. Bodyweight was maintained at 85% thereafter.
A sub-session ended either when the rats were able to acquire 10 rewards or when 10 min of the sub-session had elapsed, whichever occurred first. The associations were: left lever-press for sucrose delivery and right lever-press for food delivery . For the first 2 d, rats were trained on the FR1 schedule, where one lever press resulted in one reward delivery. Subsequently, the rats were trained on RR5 , RR10 and RR20 schedules.
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