Dryeyedisease alters how the eye's cornea heals itself after injury WUSTLmedschool PNASNews
Dry eye disease occurs when the eye can't provide adequate lubrication with natural tears. People with the common disorder use various types of drops to replace missing natural tears and keep the eyes lubricated, but when eyes are dry, the cornea is more susceptible to injury.
"We have drugs, but they only work well in about 10% to 15% of patients," said senior investigator Rajendra S. Apte, MD, Ph.D., the Paul A. Cibis Distinguished Professor in the John F. Hardesty, MD, Department of Ophthalmology & Visual Sciences.that are key to eye health, we identified potential targets for treatment that appear different in dry eyes than in healthy eyes.
The researchers analyzed genes expressed by the cornea in several mouse models—not only of dry eye disease, but also of diabetes and other conditions. They found that in
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