Elucidating the role of the gut-brain-axis in autism AutismResearch GutBrainAxis ASDPhenotypes Microbiome Metabolic DietaryPatterns Inflammation ASDInsights Neurodevelopmental NatureNeuro
By Pooja Toshniwal PahariaJun 28 2023Reviewed by Benedette Cuffari, M.Sc. In a recent study published in the journal Nature Neuroscience, researchers present a framework to utilize multi-omic data from well-defined groups and assess the contribution of gut-brain axis disruptions in the pathogenesis of autism spectrum disorder .
The gut microbiome plays a central role in regulating neuroimmune networks, modifying neural networks, and directly communicating with the brain. The metagenomic and metabolic contributions of the microbiome are crucial for understanding the functional framework of ASD. In addition, 16S rRNA sequencing differentials were calculated from a fecal matter transplantation study, including 18 pediatric ASD patients. In addition, a microbiome-diet co-occurrence analysis was performed.
Study findings Age and sex matching enhanced ASD data analysis. Differential ranking analysis revealed strong ASD-microbiome links. A functional architecture along the GBA correlated with the ASD phenotypic heterogeneity. This was characterized by ASD-associated lipid, amino acid, and carbohydrate profiles mainly encoded by Bifidobacterium, Prevotella, Bacteroides, and Desulfovibrio species and correlated with brain gene expression changes, pro-inflammatory cytokine profiles and restrictive diet patterns.
ASD phenotypes were also strongly associated with temporal gut microbial compositional alterations. In ASDs, interleukin-6 levels were upregulated, whereas Bifidobacterium, Prevotella, and Bacteroides counts were mainly associated with the cytokine differentials.
Belgique Dernières Nouvelles, Belgique Actualités
Similar News:Vous pouvez également lire des articles d'actualité similaires à celui-ci que nous avons collectés auprès d'autres sources d'information.
Insights into infant brain development: study shows how sound duration shapes auditory perceptionInsights into infant brain development: study shows how sound duration shapes auditory perception SciReports brain development childhealth auditory perception
Lire la suite »
Why we need to take the link between gut health and mental health seriouslyThere are over 140,000 different microorganisms in your gut – and they can all impact your mental and physical health. Here’s all you need to know about the link between your gut and your brain.
Lire la suite »
Canada plans brain drain of US H-1B visa holdersThey're vetted, almost acculturated, and will be booted from the US if they lose their gig
Lire la suite »
Helmet may have helped Northampton e-scooter rider, says motherKirri-Anne Hossain-Reid suffered brain damage when she was hit by a car last year.
Lire la suite »
Popular guitarist, 26, dies after 'constant brain fog' as bandmates pay tributeRyan Siew - an Australian guitarist in the upcoming rock band Polaris - has died, just months after he shared a positive update with his fans following a recent spell in hospital
Lire la suite »