Beating seizures by jamming the cellular circuitry ucsf nature NatureSMB
Present address: Department of Physiology, David Geffen School of Medicine at UCLA, Los Angeles, California, USACardiovascular Research Institute, University of California, San Francisco, California, USA
Zhou Chen, Abhisek Mondal, Fayal Abderemane Ali, Seil Jang, Sangeeta Niranjan, Balyn W. Zaro & Daniel L. Minor Jr.José L. Montaño & Balyn W. Zaro Departments of Biochemistry and Biophysics, and Cellular and Molecular Pharmacology, University of California, San Francisco, California, USACalifornia Institute for Quantitative Biomedical Research, University of California, San Francisco, California, USAKavli Institute for Fundamental Neuroscience, University of California, San Francisco, California, USAMolecular Biophysics and Integrated Bio-imaging Division, Lawrence Berkeley National Laboratory, Berkeley, California,...
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Neural dynamics and architecture of the heading direction circuit in zebrafish - Nature NeuroscienceIn this study, Petrucco, Lavian et al. identify a circuit in the hindbrain of larval zebrafish that persistently encodes heading direction. Neurons of this network, of stereotypical morphology, inhibit each other to support ring attractor dynamics.
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Identification of biomarkers for glycaemic deterioration in type 2 diabetes - Nature CommunicationsThere is an urgent need for biomarkers for type 2 diabetes progression that provide a deeper understanding of the disease process. Here, the authors identify biomarkers in three molecular classes, replicate them in other cohorts and explore top protein biomarkers in detail in functional studies.
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Incongruence between transcriptional and vascular pathophysiological cell states - Nature Cardiovascular ResearchFernández-Chacón et al. use imaging and scRNA-seq after targeting multiple Notch genes and angiogenic signaling pathways to find that the function of these pathways in vascular pathophysiology cannot be predicted by assessing transcriptional states.
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Fibroblasts are a site of murine cytomegalovirus lytic replication and Stat1-dependent latent persistence in vivo - Nature CommunicationsFibroblasts are an established cell type permissive for cytomegalovirus infection. Here the authors identify a population of fibroblast cells that can support murine cytomegalovirus lytic and latent virus infection in vivo and propose STAT1 as critically involved in murine cytomegalovirus latency.
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Robust and prototypical immune responses toward COVID-19 vaccine in First Nations peoples are impacted by comorbidities - Nature ImmunologyKedzierska et al. report an association between low production of receptor-binding domain antibodies after mRNA vaccination and altered glycosylation of IgG before vaccination in people with comorbidities, and show that this condition disproportionately affects Australia’s First Nations peoples because of the high burden of comorbidities in this population.
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What NASA Can Teach SpaceX About Environmentally Friendly Rocket LaunchesSpaceX could learn a lot from NASA about how to keep rocket launches from harming surrounding nature and wildlife.
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