The strikes are part of a long-running pay dispute, with junior doctors saying they have suffered 15 years of 'pay erosion'.
Emergency and urgent care will be prioritised over routine appointments and treatment during this week's junior doctors' strike, NHS England says.
Professor Sir Stephen said:"The NHS has been preparing extensively for the next set of strikes but managing additional pressure doesn't get easier as time goes by - it gets much more difficult, not only due to the sheer number of appointments that need to be rescheduled, but also that they can take time to rearrange with multiple teams involved.
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