A study in Annals of General Psychiatry finds that serotonergic antidepressants carry a small but significant risk of developing irreversible erectile dysfunction persisting after their discontinuation. Doctors should discuss this risk with such patients.
The number of antidepressants used per patient in the study group during the study period is reported in Table
. The majority of patients used only one antidepressant during the study period. The types of serotonergic antidepressants used during the study period varied, with SSRIs being the most frequently used .Group differences in the use of PDE-5 inhibitorspresents the study characteristics related to PDE-5 inhibitor use during the study period.
= 103.5, p < 0.001). One hundred and eighty seven subjects used one type of PDE-5 inhibitor, whereas 115 used two and 58 used all three PDE-5 inhibitors during the study period. The most commonly used PDE-5 inhibitor was sildenafil , followed by an equal number of users of tadalafil and vardenafil .The results of the logistic regression are reported in Table.
]. It could be that the higher risk of PDE-5 inhibitor treatment in patients with high SES may perhaps be due to higher awareness and referral for treatment.The issue of antidepressant-induced sexual dysfunction in general and PSSD in particular illustrates the limitations of the paradigm of short-term clinical trials with regard to drug safety.
In conclusion, our findings indicate that serotonergic antidepressants carry a small but significant risk of about 0.46% of developing an irreversible sexual dysfunction persisting after their discontinuation . As a long-term sexual disability, PSSD is a serious adverse effect of treatment with serotonergic antidepressants, and patients should be informed of its risk before their prescription.
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