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Frontiers | Dysfunctional purinergic signaling correlates with disease severity in COVID-19 patientsEctonucleotidases modulate inflammatory responses by balancing extracellular ATP and adenosine (ADO) and might be involved in COVID-19 immunopathogenesis. Here, we explored the contribution of extracellular nucleotides metabolism to COVID-19 severity in mild and severe cases of the disease. We verified that the gene expression of ectonucleotidases is reduced in the whole blood of patients with COVID-19 and is negatively correlated to CRP plasma levels, an inflammatory marker of disease severity. In line with these findings, COVID-19 patients present higher ATP levels in plasma and reduced levels of ADO when compared to healthy controls. Cell type-specific analysis revealed higher frequencies of CD39+ T cells in severely ill patients, while CD4+ and CD8+ expressing CD73 are reduced in this same group. The frequency of B cells CD39+CD73+ is also decreased during acute COVID-19. Interestingly, B cells from COVID-19 patients showed a reduced capacity to hydrolyze ATP into ADP and ADO. Furthermore, impaired expression of ADO receptors and a compromised activation of its signaling pathway is observed in COVID-19 patients. The presence of ADO in vitro, however, suppressed inflammatory responses triggered in patients’ cells. In summary, our findings support the idea that alterations in the metabolism of extracellular purines contribute to immune dysregulation during COVID-19, possibly favoring disease severity, and suggest that ADO may be a therapeutic approach for the disease.
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China expands lockdowns as COVID cases soar to daily record highChina has recorded 31,444 new COVID-19 cases - exceeding the previous peak in April when Shanghai was in a city-wide lockdown that would last two months. It is also the highest daily figure since the virus was first detected in the central Chinese city of Wuhan in late 2019.
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The Lex Newsletter: China will soothe zero-Covid misery with Korean media\n\t\t\tLet our global subject matter experts broaden your perspective with timely insights and opinions you\n\t\t\tcan’t find anywhere else.\n\t\t
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Near-Record Number Of Covid Infections Weigh On Oil Demand In China | OilPrice.comChina is registering near-record numbers of new Covid infections daily—close to the April 2022 peak when the financial center Shanghai was under lockdown for weeks
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I’m A Celebrity rocked by positive Covid cases days before 2022 finalIt has been confirmed members of the ImACeleb crew have tested positive for coronavirus, just days before the final is due to take place.
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