Every breath counts; Utilizing breath biopsy technology to detect disease early 👇 OwlstoneMedical lungcancer disease breathbiopsy interview science
insights from industryMariana LealTeam LeadOwlstone Medical Please can you introduce yourself and tell us about your role at Owlstone Medical? My name is Mariana Leal, and I am a Lead Translational Scientist – Team Lead at Owlstone Medical. Before I joined Owlstone Medical, I worked for a long time in academia, mainly in the oncology field and then in a drug discovery biotech.
Introducing Owlstone Medical - Breath Biopsy for Non-invasive BiomarkersPlay One particular focus area for Owlstone Medical is surrounding lung cancer. Why did you choose to particularly focus on this deadly disease, and how can your biopsy technology be utilized in this research field? Lung cancer is one of the leading causes of cancer-related death worldwide. A strong contributor to this fact arises from the difficulty in detecting lung cancer at an early stage.
Despite a growing body of evidence that demonstrates the potential for breath as a means to detect illnesses, there has been limited progress in developing a breath test for cancer. As well as VOCs, exogenous volatile organic compounds probes have been explored by Owlstone Medical to target various diseases.
We developed D5-ethyl-βD-glucuronide as a hydrophilic substrate probe that, upon hydrolysis by β-glucuronidase, releases D5-ethanol as a unique volatile reporter. We confirmed the cleavage of our probe by the target enzyme and, therefore, the detection of the deuterated labeled ethanol using our in vitro headspace system. It is important to highlight that a similar probe was previously tested in in vivo cancer mouse models .
For this research poster, you partnered with leading institutions and organizations in the oncology space, including Cancer Research UK, the NHS, and the University of Cambridge. How important is collaboration to your work at Owlstone Medical, and how do strong relationships and partnerships accelerate challenging research areas such as cancer? Working with others allows us to accelerate the field of breath analysis.
Analyzing VOCs produced by in vitro, ex-vivo, or in vivo, models can demonstrate mechanistic links between disease biology and biomarker candidates. These can subsequently be verified in clinical studies, sampling the same VOCs on breath, providing vital evidence that could bring diagnostic breath tests into clinical practice.
In addition, we host a Breath Biopsy Conference annually to increase the discussion and collaboration around Breath Biopsy and VOC identification.
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