Evidence A.2 lineage of monkeypox is mutating Monkeypox Virology Virus DNA Evolution biorxivpreprint icmr_niv aiims_newdelhi
Genetics & Genomics eBook Compilation of the top interviews, articles, and news in the last year.Study: Genome characterization of monkeypox cases detected in India: Identification of three sub clusters among A.2 lineage. Image Credit: NIAID
Viruses from the Poxviridae family have exhibited high inter-and intra-species recombination frequencies. Clades I and II had a genetic distance of 900 bp. The genetic changes could render transmission and infection advantages to the virus. Therefore, whole genome analyses of the circulating strains of the monkeypox virus are essential in the surveillance of the disease.
Next-generation sequencing was used for the genomic characterization of the positive samples. In addition, phylogenetic analyses were carried out on a final dataset consisting of genome sequences generated in this study and 75 sequences from the NCBI and GISAID databases that were generated pre- and post-2022 monkeypox outbreak.
The remaining three sequences from Delhi branched with USA-2022 strain ON675438.1 and formed the second sub-cluster. The third sub-cluster consisted of sequences from other U.S. and U.K strains and samples from Thailand.