Evidence for a specific anti-inflammatory metabolic signature in long-COVID AntiInflammatory Coronavirus Disease COVID PASC LongCOVID medrxivpreprint MedUni_Wien univienna
Study: Multi-omics provide evidence for an anti-inflammatory immune signature and metabolic alterations in patients with Long COVID Syndrome – an exploratory study. Image Credit: Dmitry Demidovich / ShutterstockLong COVID, also known as post-acute COVID syndrome , is a novel somatic illness group caused by the prolonged persistence of COVID-19 symptoms following acute infection.
In a thorough exploratory screening analysis, the researchers used advanced post-genomic profiling techniques on blood plasma collected from three groups: 1) symptomatic COVID-19 patients at least three months following a SARS-CoV-2 infection, referred to as LCS patients in this study, 2) COVID-19 vaccinated healthy subjects lacking exposure to the whole virus, and 3) asymptomatic fully recovered COVID-19 patients about three months post-SARS-CoV-2 infection.
Furthermore, since the most drastically down-regulated proteins in LCS patients directly influenced macrophage activity or were derived from macrophages, the identified proteome trends imply variable macrophage/monocyte polarization and function between the LCS and the recovered cohort. Independent proof of an anti-inflammatory condition was demonstrated by the patterns seen in the lipidome of LCS patients.
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