The Witcher's executive producer teases more spin-offs similar to Blood Origin
Heatworld.comand dedicated careers websiteHe secured a first-class BA journalism degree at Staffordshire University, along with several NCTJ qualifications, and now has 14 years' experience in digital publishing covering TV, movies, music, gaming, tech, showbiz, and travel.
Laurence has been a broadcasting contributor on television and radio, including KISS, Heat Radio, BBC Radio London, Radio 5 Live, and BBC Breakfast. He is also a visiting lecturer at various universities teaching journalism, including City, University of London, Nottingham Trent, Staffordshire University and London Metropolitan.
Laurence has won numerous awards in his journalism career, including the BSME Talent Award’s Best Deputy Editor, the PPA's 30 Under 30, and the New Editor and Editor of the Year at the AOP and BSMEs. He led Digital Spy to win PPA's Digital Content Team of the Year twice, along with the British Media Awards’ Brand of the Year in 2021.
Laurence joined the committee for the British Society of Magazine Editors in 2022. He has since hosted panels with CEOs of Immediate Media and the Media Trust at the PPA Festival, as well as presenting his own radio show on Green Man Radio at Green Man Festival in 2022. Laurence is also a Brits voting academy member. Laurence has been lucky enough to interview numerous celebrities, actors, and musicians throughout his career.
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This dark horror city builder is like being a mayor in The WitcherIn Gord's wonderfully grim, Slavic style, sacrificing your children to an ancient swamp horror is par for the course.
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Netflix's Far Cry anime adaptation Captain Laserhawk: A Blood Dragon Remix gets first trailerAlmost exactly two years to the day of its original announced, Netflix's exuberant animated Far Cry adaptation, Captain…
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Bradykinin B2 receptor blockade and intradialytic hypotension - BMC NephrologyIntroduction Intradialytic hypotension (IDH) is a common clinical complication and is associated with increased morbidity and mortality in patients undergoing maintenance hemodialysis (MHD). The pathogenesis of IDH has been attributed to the rapid reduction of plasma volume during hemodialysis and the inadequate compensatory mechanisms in response to hypovolemia, such as the lack of vasoconstriction. This may be due to the increased production of vasodilators, such as bradykinin. In this study we test the hypothesis that bradykinin B2 receptor blockade prevents intradialytic hypotension. Methods We performed a post-hoc analysis of a double-blind, placebo-controlled, randomized, 2 × 2 crossover clinical trial comparing the continuous infusion of icatibant, a bradykinin B2 receptor blocker, and placebo during hemodialysis. Icatibant or placebo was infused for 30 min before and during hemodialysis in 11 patients on MHD. Results Seven of the patients had IDH, defined as a reduction of systolic blood pressure equal to or greater than 20 mmHg during hemodialysis. Stratified analysis, based on the presence of IDH, revealed that icatibant prevented the decrease in blood pressure compared to placebo in patients with IDH [blood pressure at average nadir (2.5 h after hemodialysis): Placebo,114.3 ± 8.9 vs. icatibant, 125.6 ± 9.1 mmHg, mean ± S.E.M]. Icatibant did not affect blood pressure in the group of patients without IDH. Conclusion Bradykinin B2 receptor blocker may prevent the occurrence of IDH. Further studies should evaluate the hemodynamic effects of icatibant during hemodialysis and the symptomatology associated with IDH.
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The Witcher season 3 set visit - secrets from Henry Cavill's final outing as The White WolfDigital Spy had exclusive access to the set.
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Molecular characterization of a flavanone 3-hydroxylase gene from citrus fruit reveals its crucial roles in anthocyanin accumulation - BMC Plant BiologyBackground Flavanone 3-hydroxylase (F3H), a key enzyme in the flavonoid biosynthetic pathway, plays an important role in the regulation of flavonols and anthocyanidins accumulation. Citrus fruit is a rich source of flavonoids with varied flavonoid compositions among different varieties. To date, the study on F3H is limited in citrus, and its roles in regulating flavonoid accumulation in citrus fruit are still unclear. Results In this study, we isolated a CitF3H from three different citrus varieties, Satsuma mandarin (Citrus unshiu Marc.), Ponkan mandarin (C. reticulata Blanco) and blood orange ‘Moro’ (C. sinensis Osbeck). Functional analysis showed that CitF3H encoded a functional flavanone 3-hydroxylase. It catalyzed the hydroxylation of naringenin to yield dihydrokaempferol, which was a precursor of anthocyanins in flavonoid biosynthetic pathway. In the juice sacs, CitF3H was differentially expressed among the three citrus varieties, and its expression level was positively correlated with the accumulation of anthocyanins during the ripening process. In the juice sacs of Satsuma mandarin and Ponkan mandarin the expression of CitF3H kept constant at an extremely low level, and no anthocyanin was accumulated during the ripening process. In contrast, the expression of CitF3H increased rapidly along with the accumulation of anthocyanin in the juice sacs of blood orange ‘Moro’ during the ripening process. In addition, we found that blue light irradiation was effective to up-regulate the expression of CitF3H and improve anthocyanin accumulation in the juice sacs of blood orange ‘Moro’ in vitro. Conclusion CitF3H was a key gene regulating anthocyanin accumulation in the juice sacs of citrus fruit. The results presented in this study will contribute to elucidating anthocyanin biosynthesis in citrus fruit, and provide new strategies to improve the nutritional and commercial values of citrus fruit.
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The benefit of vegetarian diets for reducing blood pressure in Taiwan: a historically prospective cohort study - Journal of Health, Population and NutritionObjective Past vegetarians research has often found that they have lower blood pressure (BP). Effects may include their lower BMI and higher intake levels of fruit and vegetables. Besides, the study pursues to extend this evidence in a diverse population containing vegans, lacto-ovo vegetarians and omnivores. Design The study analyzed data on five hundred vigorous individuals aged 20 years or older from a standard medical screening program and provided validated questionnaire. Criteria were established for vegan, lacto-ovo vegetarian, partial vegetarian and omnivorous dietary patterns. Setting Health screening programs were conducted at a standard medical screening program in Taiwan between 2006 and 2017. Dietary data were gathered by self-administered questionnaire. Subjects Five hundred Taiwanese subjects representing the cohort. Results Multiple regression analyses confirmed that the vegan vegetarians had lower systolic and diastolic BP (mmHg) than omnivorous Taiwanese (β = − 6.8, p 139 mmHg or diastolic BP | 89 mmHg or routine of antihypertensive medications, the odds ratio of hypertension compared with omnivores was 0.37 (95% CI = 0.19–0.74), 0.57 (95% CI = 0.36–0.92) and 0.92 (95% CI = 0.50–1.70), respectively, for vegans, lacto-ovo vegetarians and partial vegetarians. Results were reduced after adjustment for BMI. Conclusions The study concludes from this relatively large study that vegetarians, especially vegans, with otherwise diverse characteristics but stable diets, do have lower systolic and diastolic BP and less hypertension than omnivores.
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