Aerobic exercise, specifically cycling, shows promise in reducing inflammation and boosting immune responses in the colonic tissue of Lynch syndrome patients, a group at high risk for colorectal cancer. The study suggests that regular exercise may offer a preventive approach for this patient population, though further randomized trials are needed.
By Pooja Toshniwal PahariaSep 24 2023Reviewed by Benedette Cuffari, M.Sc. In a recent study published in Clinical Cancer Research, researchers explore the role of exercise in modulating inflammation and the resident immune system in the colonic mucosa of Lynch syndrome patients.
Previous studies have shown the modulatory effects of exercise on the gut microbiome, insulin growth factor signaling, and other pathways in CRC development, thereby promoting antitumorigenic activity. In the present study, researchers investigated the influence of cycling intervention on immune system biology among LS carriers.
Participants with a personal history of non-sporadic MMR-deficient neoplasia defined by immunohistochemistry or microsatellite instability assessments or both were not included in the study. Likewise, individuals with a history of cardiovascular disease or uncontrolled medical disorders were excluded from the study.
At the initial visit, both the intervention and control groups had standard-of-care lower gastrointestinal flexible sigmoidoscopy or colonoscopy with biopsies and blood collection. Cardiopulmonary exercise testing was performed within 30 days of the endoscopy at the second appointment. The intervention and standard care groups had a third visit at the one-year endoscopy, followed by CPET at the fourth appointment within 30 days of the one-year endoscopy.
Study findings The primary outcome was a statistically significant increase in oxygen intake . In the exercise group, mean relative VO2peak increased by 26% as compared to baseline, whereas the regular care group decreased by 1.4%. Cycling exercise also reduced inflammatory prostaglandin E2 levels in the blood and colon, as well as circulating triacyl-glycerides among LS carriers allocated to the intervention group.
Belgique Dernières Nouvelles, Belgique Actualités
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