Exploring immunogenicity, boosting efficacy and safety of modified vaccinia Ankara-Bavarian Nordic vaccine Vaccine AnkaraBavarianNordicVaccine
By Pooja Toshniwal PahariaDec 7 2022Reviewed by Aimee Molineux In a recent study published in The Journal of Infectious Diseases, researchers evaluated the immunogenicity, boosting efficacy, and safety of single-dose and two-dose MVA-BN vaccinations in comparison to replicating smallpox vaccines.
The first study was a double-blinded, phase 2, non-inferiority, placebo-controlled, partially randomized clinical trial. Individuals lacking smallpox vaccination history were 1:1:1 randomized to be vaccinated 28 days apart with one MVA-BN vaccine dose and one placebo dose , two MVA-BN vaccine doses , or two tris buffer placebo doses.
The first study comprised healthy males and non-pregnant females aged between 18 years and 55 years with normal laboratory test reports at screening. The one-dose MVA-BN, two-dose MVA-BN, and PBO vaccinees were not vaccinated with any smallpox vaccines and had no identifiable vaccinia scar. MVA-BN vaccines were administered subcutaneously at ≥ 0.50 x 108 tissue culture infectious dose MVA-BN doses.
After nearly two years, 304 individuals and 121 HSPX+ individuals provided specimens for humoral protection assessments. In total, 77 one-dose MVA-BN vaccinees and 75 two-dose MVA-BN vaccinees, respectively, received MVA-BN BD.
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