A novel antibody-drug conjugate continues to demonstrate superior benefit for patients with HR+, HER2- metastatic breast cancer when compared to standard chemotherapy, according to a new study in The Lancet.
Overall survival in the intention-to-treat population. This is the planned final analysis of overall survival in the intent-to-treat population of all randomly assigned patients. Vertical hash marks indicate censored data.
The sacituzumab group also showed superior response rates as well as prolonged median progression-free survival when compared to standard chemotherapy. Patients treated with sacituzumab had a 34% lower risk of cancer progression or death than those treated with chemotherapy. "These data reinforce that sacituzumab govitecan is leading to improvements in both progression- free and overall survival and that patients saw benefit irrespective of their tumor's Trop-2 expression," says Sara Tolaney, MD, MPH, chief of the Division of Breast Oncology at the Susan F. Smith Center for Women's Cancers at Dana-Farber and the study's senior author.
Earlier data from the TROPICs-02 study that was presented at last year's ASCO annual meeting as well at the European Society for Medical Oncology conference led to the accelerated FDA approval of sacituzumab govitecan for the treatment of metastatic HR+/HER2- breast cancer in February of this year. The first authors of the study are Hope S. Rugo, MD, of the University of California-San Francisco and the Helen Diller Family Comprehensive Cancer Center, and Aditya Bardia, MD, MPH, of Massachusetts General Hospital Cancer Center.
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