First trial to prove a diet supplement can prevent hereditarycancer
An international trial—known as CAPP2—involved almost 1000 patients with Lynch syndrome from around the world, and revealed that a regular dose of, also known as fermentable fiber, taken for an average of two years, did not affect cancers in the bowel but did reduce cancers in other parts of the body by more than half. This effect was particularly pronounced for upper gastrointestinal cancers including esophageal, gastric, biliary tract, pancreatic and duodenum cancers.
"Resistant starch can be taken as a powder supplement and is found naturally in peas, beans, oats and other starchy foods. The dose used in the trial is equivalent to eating a daily banana; before they become too ripe and soft, the starch in bananas resists breakdown and reaches the bowel where it can change the type of bacteria that live there.
Professor Sir John Burn, from Newcastle University and Newcastle Hospitals NHS Foundation Trust, who ran the trial with Professor Mathers, said,"When we started the studies over 20 years ago, we thought that people with a genetic predisposition to colon cancer could help us to test whether we could reduce the risk of cancer with either aspirin or resistant starch.
"Based on our trial, NICE now recommend aspirin for people at high genetic risk of cancer; the benefits are clear—aspirin and resistant starch work."Between 1999 and 2005, nearly 1000 participants began either taking resistant starch in a powder form every day for two years, or aspirin or a placebo.
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