Study finds folicacid treatment is associated with decreased risk of suicideattempts JAMAPsych
In this cohort study, a within-person pharmacoepidemiologic study that included 866 586 adults, folic acid treatment was associated with a significantly reduced rate of suicidal events. This large-scale observational study confirmed results of an earlier signal-generation study.Folic acid may be an inexpensive and widely available suicide prevention tool; a large-scale randomized clinical trial is warranted.
International Statistical Classification of Diseases, Ninth and Tenth Revisions, Clinical ModificationData on 866 586 patients were collected; 704 514 were female, and 90 296 were 60 years and older. Overall, there were 261 suicidal events during months covered by a folic acid prescription for a rate of 4.73 per 100 000 person-months, compared with 895 suicidal events during months without folic acid for a rate of 10.61 per 100 000 person-months.
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