Forxiga (dapagliflozin) approved for symptomatic chronic heat failure
From AstraZenecaDec 12 2022 • Today’s decision from the Medicines and Healthcare products Regulatory Agency marks the approval of dapagliflozin for the treatment of symptomatic chronic heart failure and left ventricular ejection fraction >40%, including HF with mildly reduced ejection fraction and preserved ejection fraction .1
HF is a life-threatening chronic disease in which the heart cannot pump enough blood around the body, affecting almost one million people in the UK, with approximately 270,000 living with the condition undiagnosed.3,7 There are three main categories of HF related to ejection fraction , a measurement of the percentage of blood leaving the heart each time it contracts, including: HFrEF , HFmrEF and HFpEF .
Related StoriesAdditionally, the pre-specified, patient level, pooled analysis of the DELIVER and DAPA-HF Phase III trials demonstrated that dapagliflozin reduced the risk of CV death by 14% over the median follow-up of 22 months, death from any cause by 10% , total hospitalisation for HF by 29% and the composite of death from CV causes, myocardial infarction, or stroke by 10% in patients with HF irrespective of LVEF.
References 1. Electronic Medicines Compendium . Forxiga 10 mg film-coated tablets. Summary of Product Characteristics . Available at: https://www.medicines.org.uk/emc/product/7607/smpc#gref. Last accessed December 2022.
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