This month celebrates the 20th anniversary of the Human Genome Project (HGP), which coincides with the 7th birthday of MGI_Technology. In the below interview with Radoje Drmanac from MGI and CompleteGenomic, we look back at where the HGP began. 👇
insights from industryDr. Radoje DrmanacChief Scientific Officer at MGICo-Founder of Complete Genomics The Human Genome Project was an international scientific research project set out to map, identify, and sequence all the genes that make up the human genome, as well as improve the tools for data analysis for the future deciphering of genetic information. The project began in 1990 and was completed in 2003.
Then, as a postdoc in 1991, through this connection with the DOE, the whole team – all nine of us – moved to Argonne National Laboratory near Chicago in the US to continue to develop sequencing by hybridization technology using the DOE grants. When we started Complete Genomics, within a couple of years of implementation, we achieved a milestone, an event that promoted the genomic revolution. We sequenced and published in the journal Science in 2010, for the first time, a whole human genome for $5,000, a 10-fold improvement, using patterned DNA arrays of DNA nanoballs, a much more efficient, higher-density sequencing platform.
All things considered, it was really rewarding when, with a long-time friend and colleague, Lee Hood, we decided to sequence the first family. We sequenced a family of four, two parents and their two children who were affected with a disease called Miller Syndrome, to prove that we could identify the cause of Miller Syndrome in the affected children.
We have seen in recent years that sequencing is the key to accelerating the field of omics. What role have both Complete Genomics and MGI played in this discovery, and what role will they continue to play in its future? We have always pushed the boundaries, starting with the $5,000 genome, which was so important. In a way, it proved that routine genome sequencing was possible and that there is value in individual genome sequencing.
Combining the efficient sequencing with our single tube LFR technology for haplotype phasing, solving blind spots by resolving the pseudogenes, separating pseudogenes from the real genes, and using these longer reads all redefines massively parallel sequencing and brings it to the level that will enable faster understanding of our genetic program. With this understanding, our omics tests will be so efficient that we can bring health monitoring omics to all.
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