T-cell vaccine for COVID-19 may last longer than current vaccines penn_state frontiersin
To generate a vaccine with the potential to generate broader protection and with less likelihood of being subject to antigenic drift, we designed and preclinically tested a T-cell vaccine composed of fullypredicted epitopes sampled from the entire SARS-CoV-2 genome using the RAVEN™ computational platform. In summary, we show that such a vaccine, delivered as a plasmid DNA vaccine, induces reactive T cells to respond to 15 out of the 17 included epitopes in immunized C57BL/6J mice.
Coding sequences from full-length SARS-CoV-2 proteins were used for deep learning-based MHC class I and class II ligand prediction using H-2-Kb and H-2-Db and the H-2-Iab alleles, respectively, with tools developed in house.
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Post-COVID-19 condition and persisting symptoms in English schoolchildren: repeated surveys to March 2022 - BMC Infectious DiseasesBackground Both post-COVID-19 condition (long COVID) and the presence of persisting symptoms that do not meet formal definitions of post-COVID-19-condition may adversely affect quality of life and function. However, their prevalence among children and young people in England is unclear. Methods We used data from repeated surveys in a large cohort of English schoolchildren from the COVID-19 Schools Infection Survey (SIS) for the school year 2021/22 to describe the weighted prevalence of post-COVID-19-condition and compare persisting symptoms between individuals with a positive SARS-CoV-2 test and those with neither a positive test history nor suspected infection. Results Among 7797 children from 173 schools, 1.8% of primary school pupils (aged 4 to 11 years), 4.5% of secondary school pupils in years 7–11 (aged 11 to 16 years) and 6.9% of those in years 12–13 (aged 16 to 18 years) met a definition of post-COVID-19 condition in March 2022. Specific persisting symptoms such as anxiety or difficulty concentrating were frequently reported regardless of prior infection status and increased with age: 48.0% of primary school pupils, 52.9% of secondary school pupils in years 7–11 and 79.5% in years 12–13 reporting at least one symptom lasting more than 12 weeks. Persisting loss of smell and taste, cardiovascular and some systemic symptoms were more frequently reported by those with a previous positive test. Conclusions We showed that ongoing symptoms were frequently reported by English schoolchildren regardless of SARS-CoV-2 test results and some specific symptoms such as loss of smell and taste were more prevalent in those with a positive test history. Our study emphasises the wide-ranging impacts of the COVID-19 pandemic on the health and wellbeing of children and young people.
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