Morning blue light treatment improves sleep in patients with PTSD frontiersin
, shows that the final phase of the fear conditioning paradigm was to examine brain activation patterns to the same stimuli during functional magnetic resonance imaging . An important consideration is that prior to the fMRI scan, the CS + U image was also “extinguished” by presenting the CS + E and CS + U in the extinction context eight more times, as part of the standard fear conditioning protocol to ensure no latent adverse experiment effects related to a sustained conditioned fear response.
Image processing and statistical analysis were undertaken in SPM12 following a standard pipeline that involved image realignment, unwarping, co-registration, normalization to Montreal Neurological Institute coordinate space, spatial smoothing , and reslicing to 2 × 2 × 2 mm voxels. A high pass filter was implemented to remove low frequency confounds, and the Artifact Detection Toolwas used to remove motion artifacts and outlier scans that exceeded 3 SD in mean global intensity.
Participants showed a decline in PTSD symptoms and severity between baseline and post-treatment assessments. There was a strong effect of time on both PTSD severity,, as assessed by the Clinician-Administered PTSD Scale . There was also a decrease in PTSD symptoms, as assessed by the PTSD checklist ,
Belgique Dernières Nouvelles, Belgique Actualités
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