The best protection against COVID-19 could be a vaccine delivered through the nose, according to new paper frontiersin
Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, United StatesDepartment of Microbiology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, United StatesLaboratory of Cellular and Molecular Immunology, Institute of Microbiology of the Czech Academy of Sciences, Prague, Czechia
SARS-CoV-2 is primarily an airborne infection of the upper respiratory tract, which on reaching the lungs causes the severe acute respiratory disease, COVID-19. Its first contact with the immune system, likely through the nasal passages and Waldeyer’s ring of tonsils and adenoids, induces mucosal immune responses revealed by the production of secretory IgA antibodies in saliva, nasal fluid, tears, and other secretions within 4 days of infection.