New cholera substrains in Bangladesh uncovered by genomic surveillance confirm the importance of vaccination NatureComms
. This may explain the higher frequency of purging events and/or prevalence of LWS over RWS observed in patients infected with Clade 3 strains. Speculating further, it is possible that the increased frequency of purging associated with Clade 3 may result in increased rates of transmission and could therefore contribute to its global distribution, compared to Clade 5. Notably, the number of purging events was also lower in vaccinated patients than unvaccinated ones.
In addition to strain differences, our data also show that different groups living within Cox’s Bazar might be at different levels of risk of more severe disease. For example, we observed a higher prevalence of RWS in the adjacent host population than the FDMNs, and a higher proportion of FDMNs had limited or severe dehydration than the BGDNs, both of which agree with results from a recent epidemiological study on the same population.
Here we showed that the isolates causing sporadic disease in the Rohingya and Bangladesh host population belonged to the high-risk 7PETclone still causing large-scale cholera epidemics globally. Given the risk posed by this lineage, it’s difficult not to conclude that the pre-emptive mass vaccination campaign played an important role in preventing an epidemic within a highly vulnerable community .
Belgique Dernières Nouvelles, Belgique Actualités
Similar News:Vous pouvez également lire des articles d'actualité similaires à celui-ci que nous avons collectés auprès d'autres sources d'information.
Metabolic clogging of mannose triggers dNTP loss and genomic instability in human cancer cellsNew study helps explain the anti-cancer properties of mannose sugar sbpdiscovery elife
Lire la suite »
A framework for individualized splice-switching oligonucleotide therapy - NatureWhole-genome sequencing analyses in a cohort of individuals with ataxia-telangiectasia are used to identify genetic variants that might be amenable to treatment with splice-switching antisense oligonucleotides (ASOs), and develop ASOs with therapeutic potential.
Lire la suite »
Typhoon Talim lashes China as extreme weather grips AsiaThe storm has displaced hundreds of thousands, disrupted public transport and shut tourist spots.
Lire la suite »
Metabolic clogging of mannose triggers dNTP loss and genomic instability in human cancer cellsNew study helps explain the anti-cancer properties of mannose sugar sbpdiscovery elife
Lire la suite »
Ofcom investigates campaign on Ken Bruce radio showGreatest Hits Radio's campaign around offenders attending sentencing is under scrutiny.
Lire la suite »