Neuroscientists at Scripps Research have identified brain circuits that make mammals want to eat more when they are exposed to cold temperatures.
Mammals automatically burn more energy to maintain normal body temperature when exposed to cold. This cold-activated increase in
One drawback of cold therapies is that humans' evolved responses to cold are not designed to cause weight loss . Cold, like dieting and exercise, increases appetite to counteract any weight-loss effect. In the study, Ye and his team set out to identify the brain circuitry that mediates this cold-induced appetite increase.
Using techniques called whole-brain clearing and light sheet microscopy, the researchers compared the activity of neurons across the brain during cold versus warm conditions. Soon they made a key observation: While most of the neuronal activity across the brain was much lower in the cold condition, portions of a region called the thalamus showed higher activation.
When the researchers artificially activated these neurons, the mice increased their food-seeking, but not other activities. Similarly, when the team inhibited the activity of these neurons, the mice decreased their food-seeking. These effects appeared only under the cold condition, implying thatprovide a separate signal that must also be present for appetite changes to occur.
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